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anti human il 12p70  (R&D Systems)


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    R&D Systems anti human il 12p70
    Sorted naïve CD8 T cells were activated with CD3/CD28 beads for 24 hours, rested for 2 days and restimulated with CD3/CD28 beads for 8 days in the presence of the indicated cytokines with or without TGF-β. a Data from a representative donor and ( b ) summary of NKG2A expression after 8 days of culture are shown ( n = 5). c Expression of NKG2A by CD8 T cells after stimulation of PBMC with SEB in the presence of isotype control, <t>α-IL-12p70</t> Ab, α-CD40 Ab or both. Data from one representative donor are shown. d Summary of ( c ) (left) and percentage inhibition of NKG2A expression by CD8 T cells in the different culture conditions (right) ( n = 4). e Detection of IL-12p70 in the culture supernatants of PBMCs stimulated for 3 days with SEB in presence or not of α-CD40 Ab (left) and percentage inhibition of IL-12p70 secretion (right) ( n = 3). b , d , e Data are from distinct healthy donors. Horizontal lines indicate the mean ± SEM. NS= non-significant; p -values were determined by one-way ANOVA with Tukey’s post hoc test ( b , d , g ).
    Anti Human Il 12p70, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 67 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti human il 12p70/product/R&D Systems
    Average 93 stars, based on 67 article reviews
    anti human il 12p70 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells"

    Article Title: IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells

    Journal: Nature Communications

    doi: 10.1038/s41467-024-54420-w

    Sorted naïve CD8 T cells were activated with CD3/CD28 beads for 24 hours, rested for 2 days and restimulated with CD3/CD28 beads for 8 days in the presence of the indicated cytokines with or without TGF-β. a Data from a representative donor and ( b ) summary of NKG2A expression after 8 days of culture are shown ( n = 5). c Expression of NKG2A by CD8 T cells after stimulation of PBMC with SEB in the presence of isotype control, α-IL-12p70 Ab, α-CD40 Ab or both. Data from one representative donor are shown. d Summary of ( c ) (left) and percentage inhibition of NKG2A expression by CD8 T cells in the different culture conditions (right) ( n = 4). e Detection of IL-12p70 in the culture supernatants of PBMCs stimulated for 3 days with SEB in presence or not of α-CD40 Ab (left) and percentage inhibition of IL-12p70 secretion (right) ( n = 3). b , d , e Data are from distinct healthy donors. Horizontal lines indicate the mean ± SEM. NS= non-significant; p -values were determined by one-way ANOVA with Tukey’s post hoc test ( b , d , g ).
    Figure Legend Snippet: Sorted naïve CD8 T cells were activated with CD3/CD28 beads for 24 hours, rested for 2 days and restimulated with CD3/CD28 beads for 8 days in the presence of the indicated cytokines with or without TGF-β. a Data from a representative donor and ( b ) summary of NKG2A expression after 8 days of culture are shown ( n = 5). c Expression of NKG2A by CD8 T cells after stimulation of PBMC with SEB in the presence of isotype control, α-IL-12p70 Ab, α-CD40 Ab or both. Data from one representative donor are shown. d Summary of ( c ) (left) and percentage inhibition of NKG2A expression by CD8 T cells in the different culture conditions (right) ( n = 4). e Detection of IL-12p70 in the culture supernatants of PBMCs stimulated for 3 days with SEB in presence or not of α-CD40 Ab (left) and percentage inhibition of IL-12p70 secretion (right) ( n = 3). b , d , e Data are from distinct healthy donors. Horizontal lines indicate the mean ± SEM. NS= non-significant; p -values were determined by one-way ANOVA with Tukey’s post hoc test ( b , d , g ).

    Techniques Used: Expressing, Control, Inhibition



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    Image Search Results


    Sorted naïve CD8 T cells were activated with CD3/CD28 beads for 24 hours, rested for 2 days and restimulated with CD3/CD28 beads for 8 days in the presence of the indicated cytokines with or without TGF-β. a Data from a representative donor and ( b ) summary of NKG2A expression after 8 days of culture are shown ( n = 5). c Expression of NKG2A by CD8 T cells after stimulation of PBMC with SEB in the presence of isotype control, α-IL-12p70 Ab, α-CD40 Ab or both. Data from one representative donor are shown. d Summary of ( c ) (left) and percentage inhibition of NKG2A expression by CD8 T cells in the different culture conditions (right) ( n = 4). e Detection of IL-12p70 in the culture supernatants of PBMCs stimulated for 3 days with SEB in presence or not of α-CD40 Ab (left) and percentage inhibition of IL-12p70 secretion (right) ( n = 3). b , d , e Data are from distinct healthy donors. Horizontal lines indicate the mean ± SEM. NS= non-significant; p -values were determined by one-way ANOVA with Tukey’s post hoc test ( b , d , g ).

    Journal: Nature Communications

    Article Title: IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells

    doi: 10.1038/s41467-024-54420-w

    Figure Lengend Snippet: Sorted naïve CD8 T cells were activated with CD3/CD28 beads for 24 hours, rested for 2 days and restimulated with CD3/CD28 beads for 8 days in the presence of the indicated cytokines with or without TGF-β. a Data from a representative donor and ( b ) summary of NKG2A expression after 8 days of culture are shown ( n = 5). c Expression of NKG2A by CD8 T cells after stimulation of PBMC with SEB in the presence of isotype control, α-IL-12p70 Ab, α-CD40 Ab or both. Data from one representative donor are shown. d Summary of ( c ) (left) and percentage inhibition of NKG2A expression by CD8 T cells in the different culture conditions (right) ( n = 4). e Detection of IL-12p70 in the culture supernatants of PBMCs stimulated for 3 days with SEB in presence or not of α-CD40 Ab (left) and percentage inhibition of IL-12p70 secretion (right) ( n = 3). b , d , e Data are from distinct healthy donors. Horizontal lines indicate the mean ± SEM. NS= non-significant; p -values were determined by one-way ANOVA with Tukey’s post hoc test ( b , d , g ).

    Article Snippet: For IL-12p70 and CD40L blocking experiments, anti-Human Il-12p70 (R&D Systems, cat #MAB219-100, 10 µg/ml final), anti-CD40 (BioLegend, cat #313019, clone HB14, 10 µg/ml final) or isotype control mouse IgG1 (BioLegend, cat #400166, clone MOPC21, 10 µg/ml final) were added in the corresponding wells.

    Techniques: Expressing, Control, Inhibition

    List of antibodies used for monocyte flow cytometry

    Journal: The Journal of Clinical Endocrinology and Metabolism

    Article Title: Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels

    doi: 10.1210/clinem/dgae097

    Figure Lengend Snippet: List of antibodies used for monocyte flow cytometry

    Article Snippet: IL12 (p40/p70) , Miltenyi , 130-123-312 , AB_2921743.

    Techniques:

    Percentage of IL6 (A), IL-1β (B), TNF (C), and IL12 producing CD14 + monocytes (D) under pathogenic stimulation after treatment with placebo (white) and magnesium (gray). S. Aureus, Staphylococcus aureus ; Mtb, Mycobacterium tuberculosis . Data are presented as median and individual values.

    Journal: The Journal of Clinical Endocrinology and Metabolism

    Article Title: Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels

    doi: 10.1210/clinem/dgae097

    Figure Lengend Snippet: Percentage of IL6 (A), IL-1β (B), TNF (C), and IL12 producing CD14 + monocytes (D) under pathogenic stimulation after treatment with placebo (white) and magnesium (gray). S. Aureus, Staphylococcus aureus ; Mtb, Mycobacterium tuberculosis . Data are presented as median and individual values.

    Article Snippet: IL12 (p40/p70) , Miltenyi , 130-123-312 , AB_2921743.

    Techniques: